What are side effects of Medroxyprogesterone Injection (Depo-Provera)?

May 3, 2024
1 - 2 minute read
Dr. Elena Chan @ Women's Health Center of Silicon Valley

Depo-Provera is a widely-used contraceptive injection containing medroxyprogesterone acetate, a synthetic form of the hormone progesterone. Administered every 12 weeks, it prevents pregnancy by inhibiting ovulation, thickening cervical mucus, and thinning the uterine lining.

  1. Irregular Bleeding: Unlike combined birth control pills, Depo-Provera may cause irregular bleeding or no periods due to continuous hormone release. While bleeding is typically less, it can still be bothersome.
  2. Weight Gain: Some users report weight gain while on Depo-Provera, possibly due to hormonal changes and increased appetite.
  3. Bone Loss: Long-term use may increase the risk of bone loss, especially in younger women. However, this is reversible upon discontinuation.
  4. Delayed Fertility: Unlike some contraceptives, fertility may not return immediately after stopping Depo-Provera. Prolonged use can lead to months of infertility.

Depo-Provera offers effective contraception, but it's important to consider its side effects. Discuss your medical history and preferences with your healthcare provider to make an informed decision that aligns with your reproductive goals. Stay proactive and informed to safeguard your reproductive health effectively.

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